Professor Armstrong’s lab works in the area of systems neurobiology with both informatics and wet-lab based research programmes.
SHEDDING LIGHT ON THE COMPLEX WORLD OF NEURONAL PROTEINS
Many neurological disorders, even those with symptoms recognisable in adults, have their origins in the earliest stages of life. The networks of proteins that we study are enriched with genes already linked to multi-factorial developmental disorders including autism spectrum disorders (ASDs).
My lab is developing and applying methods that are already helping to uncover some key relationships between these genes and proteins and may even help to provide new insights into how the diseases work. We focus on trying to understand and dissect molecular complexity in the brain. Rather than looking in detail at single genes or proteins, we study how groups of these genes and proteins come together to underpin the development, anatomy and function of the nervous system.
Much of our work focuses on the complex networks of proteins at synapses that mediate the messages between neurons. We collaborate extensively with researchers nationally and internationally and we have laboratory based work, which uses Drosophila — fruit flies — as a model system for ASD.