Andrew McKechanie

Dr Andrew McKechanie is a Senior Clinical Research Fellow at The Patrick Wild Centre and a Consultant Psychiatrist in Intellectual Disability working in East Lothian.

My research principally relates to individuals with intellectual disabilities caused by identified genetic changes; and in particular fragile X syndrome and SYNGAP1-realted intellectual disability.  Previously I have used brain-imaging and genetic techniques to try to identify the underlying neurobiology of these conditions.

This is an example of data from Magnetic Resonance Imaging (MRI) through the brain of an individual with fragile X syndrome, the most common inherited form of intellectual disability. The coloured areas show the brain regions that are active while looking at a fearful face. We have used this technique to examine how brains of people with fragile X syndrome process information such as emotion and fear.

I am now collaborating with colleagues in genetics and public health to look at what we can learn from routinely-acquired clinical and administrative data to inform our understanding of the health, health needs and healthcare usage of individuals with identified forms of intellectual disability.

Email: [email protected]

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